{"id":19774,"date":"2023-05-03T14:50:53","date_gmt":"2023-05-03T14:50:53","guid":{"rendered":"https:\/\/2023.biowars.com\/blog\/?p=19774"},"modified":"2023-05-03T14:50:53","modified_gmt":"2023-05-03T14:50:53","slug":"monocytes-explained","status":"publish","type":"post","link":"https:\/\/2023.biowars.com\/blog\/monocytes-explained\/","title":{"rendered":"Monocytes 101: Types, Function And Importance Of The Immune System\u2019s MVPs"},"content":{"rendered":"<p style=\"font-size: 10pt; text-align: center;\">Discover the role of monocytes in the immune system!<\/p>\n<p><span data-contrast=\"auto\">Did you know that your immune system can be resentful, but in a cool way?<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">It <\/span><a href=\"https:\/\/www.betterhealth.vic.gov.au\/health\/conditionsandtreatments\/immune-system\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">remembers every single microbe it has ever fought<\/span><\/a><span data-contrast=\"auto\">, so if the bad guys enter your body again, your immune system recognizes them and quickly destroys them before they cause you harm.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Some of the most important cells that make up your immune system are called monocytes. <\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">They\u2019re like your body\u2019s soldiers that are crucial for protecting you from bacteria and viruses.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">But how do monocytes do it? Why are they so important? Let\u2019s find out!<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p style=\"text-align: center;\"><a class=\"mceNonEditable cta-custom\" href=\"https:\/\/2023.biowars.com\/comic\" target=\"_blank\" rel=\"noopener\">Uncover the battle raging within. Read the BIOWARS comic book for free!<\/a><\/p>\n<h2 aria-level=\"2\"><span data-contrast=\"none\">What Are Monocytes?<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><b><span data-contrast=\"auto\">Monocytes are a type of white blood cells that are crucial for your body\u2019s immune response.\u00a0<\/span><\/b><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">As a white blood cell, they\u2019re the MVPs of your immune system.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">White blood cells include:<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Monocytes<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Granulocytes (<\/span><a href=\"https:\/\/2023.biowars.com\/blog\/the-biology-of-biowars-the-neutrophil-necessity\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">neutrophils<\/span><\/a><span data-contrast=\"auto\">, eosinophils and basophils)<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"7\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Lymphocytes (<\/span><a href=\"https:\/\/2023.biowars.com\/blog\/types-of-t-cells\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">T-Cells<\/span><\/a><span data-contrast=\"auto\"> and <\/span><a href=\"https:\/\/2023.biowars.com\/blog\/what-are-b-cells\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">B-Cells<\/span><\/a><span data-contrast=\"auto\">)<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<\/ul>\n<div id=\"attachment_19777\" style=\"width: 810px\" class=\"wp-caption aligncenter\"><img aria-describedby=\"caption-attachment-19777\" loading=\"lazy\" class=\"size-full wp-image-19777\" src=\"https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-white-blood-cells-1.jpg\" alt=\"A stock image showing what white blood cells look like.\u200b\" width=\"800\" height=\"282\" srcset=\"https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-white-blood-cells-1.jpg 800w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-white-blood-cells-1-300x106.jpg 300w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-white-blood-cells-1-768x271.jpg 768w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-white-blood-cells-1-440x155.jpg 440w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-white-blood-cells-1-635x224.jpg 635w\" sizes=\"(max-width: 800px) 100vw, 800px\" \/><p id=\"caption-attachment-19777\" class=\"wp-caption-text\">White blood cells are the elite warriors of your immune system. \u200b<\/p><\/div>\n<p><span data-contrast=\"auto\">All white blood cells are part of your lymphatic system \u2014 think of them as a team of superheroes that work together to keep you healthy.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes, in particular, are important for your well-being.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">They are a part of your <\/span><b><span data-contrast=\"auto\">innate immune system<\/span><\/b><span data-contrast=\"auto\">, which means that they\u2019re in your body\u2019s first line of defense against invaders. Monocytes recognize and eliminate pathogens and all damaged cells. <\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes are also <\/span><b><span data-contrast=\"auto\">the largest type of white blood cell<\/span><\/b><span data-contrast=\"auto\">. They average <\/span><a href=\"https:\/\/www.britannica.com\/science\/blood-biochemistry\/White-blood-cells-leukocytes#ref62367\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">15 \u2013 18\u03bcm<\/span><\/a><span data-contrast=\"auto\"> in diameter (like specks of dust!) and are approximately two times bigger than red blood cells.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Under a microscope, monocytes appear as large, <\/span><b><span data-contrast=\"auto\">round or kidney-shaped cells<\/span><\/b><span data-contrast=\"auto\"> with a distinct nucleus.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p aria-level=\"2\"><span data-contrast=\"auto\">They belong to a group of cells called <\/span><b><span data-contrast=\"auto\">agranulocytes<\/span><\/b><span data-contrast=\"auto\"> \u2014 this means that they don\u2019t contain granules in their cytoplasm.\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Remember what cytoplasm is?\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">It\u2019s like the jelly inside a donut. Except that in this case, the jelly is reallllly gooey and it gives the shape to a cell instead of to a donut. Cytoplasm is found inside all living cells, including the cells in your body!<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p aria-level=\"2\"><span data-contrast=\"auto\">Unlike granulocytes, which have distinct granules visible in their cytoplasm, monocytes have a relatively uniform appearance with a <\/span><b><span data-contrast=\"auto\">smooth<\/span><\/b> <b><span data-contrast=\"auto\">cytoplasm<\/span><\/b><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The specialized granules that are found in granulocytes are important for functions such as fighting infections and producing inflammation. But, this doesn\u2019t mean that monocytes are powerless.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In fact, these cells are in charge of performing a variety of important immune system functions, including phagocytosis, antigen presentation and cytokine production! More on these soon!<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<h2 aria-level=\"2\"><span data-contrast=\"none\">The Development Of Monocytes<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Like all white blood cells, monocytes are also produced in the <\/span><b><span data-contrast=\"auto\">bone marrow<\/span><\/b><span data-contrast=\"auto\"> \u2014 the spongy mass inside your bones.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">They develop from <\/span><b><span data-contrast=\"auto\">hematopoietic stem cells<\/span><\/b><span data-contrast=\"auto\"> \u2014 these guys can create all types of blood cells.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">When hematopoietic stem cells divide, they can produce <\/span><b><span data-contrast=\"auto\">two types of immune system cells<\/span><\/b><span data-contrast=\"auto\">:\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<ul>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">More stem cells\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<li data-leveltext=\"\uf0b7\" data-font=\"Symbol\" data-listid=\"9\" data-list-defn-props=\"{&quot;335552541&quot;:1,&quot;335559684&quot;:-2,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769226&quot;:&quot;Symbol&quot;,&quot;469769242&quot;:[8226],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;\uf0b7&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><span data-contrast=\"auto\">Specialized cells called <\/span><b><span data-contrast=\"auto\">progenitor<\/span><\/b><span data-contrast=\"auto\"> cells; progenitor cells then produce different types of blood cells, including monocytes<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<\/ul>\n<p><span data-contrast=\"auto\">Once monocytes fully develop in the bone marrow, they get into your bloodstream and travel throughout the body.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">As soon as a tissue is damaged or infected, monocytes are urgently recruited to that tissue.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Once they get inside the tissue, monocytes differentiate into two types of immune system cells:\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<ol>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:767,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><a href=\"https:\/\/2023.biowars.com\/blog\/macrophages-function\/\"><b><span data-contrast=\"none\">Macrophages<\/span><\/b><\/a><b><span data-contrast=\"auto\">:<\/span><\/b><span data-contrast=\"auto\"> These cells engulf and digest pathogens, foreign substances and cellular debris.<\/span><\/li>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"8\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:767,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Dendritic cells: <\/span><\/b><span data-contrast=\"auto\">Dendritic cells help identify and present antigens to other immune cells. They also initiate the response of the adaptive immune system.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<\/ol>\n<p><span data-contrast=\"auto\">Once monocytes differentiate into macrophages and dendritic cells, they start participating in your body\u2019s protection against pathogens.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<blockquote class=\"instagram-media\" style=\"background: #FFF; border: 0; border-radius: 3px; box-shadow: 0 0 1px 0 rgba(0,0,0,0.5),0 1px 10px 0 rgba(0,0,0,0.15); margin: 1px; max-width: 540px; min-width: 326px; padding: 0; width: calc(100% - 2px);\" data-instgrm-permalink=\"https:\/\/www.instagram.com\/p\/CO79mRbjZ6d\/?utm_source=ig_embed&amp;utm_campaign=loading\" data-instgrm-version=\"14\">\n<div style=\"padding: 16px;\">\n<p>&nbsp;<\/p>\n<div style=\"display: flex; flex-direction: row; align-items: center;\">\n<div style=\"background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 40px; margin-right: 14px; width: 40px;\"><\/div>\n<div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center;\">\n<div style=\"background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 100px;\"><\/div>\n<div style=\"background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 60px;\"><\/div>\n<\/div>\n<\/div>\n<div style=\"padding: 19% 0;\"><\/div>\n<div style=\"display: block; height: 50px; margin: 0 auto 12px; width: 50px;\"><\/div>\n<div style=\"padding-top: 8px;\">\n<div style=\"color: #3897f0; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: 550; line-height: 18px;\">View this post on Instagram<\/div>\n<\/div>\n<div style=\"padding: 12.5% 0;\"><\/div>\n<div style=\"display: flex; flex-direction: row; margin-bottom: 14px; align-items: center;\">\n<div>\n<div style=\"background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(0px) translateY(7px);\"><\/div>\n<div style=\"background-color: #f4f4f4; height: 12.5px; transform: rotate(-45deg) translateX(3px) translateY(1px); width: 12.5px; flex-grow: 0; margin-right: 14px; margin-left: 2px;\"><\/div>\n<div style=\"background-color: #f4f4f4; border-radius: 50%; height: 12.5px; width: 12.5px; transform: translateX(9px) translateY(-18px);\"><\/div>\n<\/div>\n<div style=\"margin-left: 8px;\">\n<div style=\"background-color: #f4f4f4; border-radius: 50%; flex-grow: 0; height: 20px; width: 20px;\"><\/div>\n<div style=\"width: 0; height: 0; border-top: 2px solid transparent; border-left: 6px solid #f4f4f4; border-bottom: 2px solid transparent; transform: translateX(16px) translateY(-4px) rotate(30deg);\"><\/div>\n<\/div>\n<div style=\"margin-left: auto;\">\n<div style=\"width: 0px; border-top: 8px solid #F4F4F4; border-right: 8px solid transparent; transform: translateY(16px);\"><\/div>\n<div style=\"background-color: #f4f4f4; flex-grow: 0; height: 12px; width: 16px; transform: translateY(-4px);\"><\/div>\n<div style=\"width: 0; height: 0; border-top: 8px solid #F4F4F4; border-left: 8px solid transparent; transform: translateY(-4px) translateX(8px);\"><\/div>\n<\/div>\n<\/div>\n<div style=\"display: flex; flex-direction: column; flex-grow: 1; justify-content: center; margin-bottom: 24px;\">\n<div style=\"background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; margin-bottom: 6px; width: 224px;\"><\/div>\n<div style=\"background-color: #f4f4f4; border-radius: 4px; flex-grow: 0; height: 14px; width: 144px;\"><\/div>\n<\/div>\n<p>&nbsp;<\/p>\n<p style=\"color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; line-height: 17px; margin-bottom: 0; margin-top: 8px; overflow: hidden; padding: 8px 0 7px; text-align: center; text-overflow: ellipsis; white-space: nowrap;\"><a style=\"color: #c9c8cd; font-family: Arial,sans-serif; font-size: 14px; font-style: normal; font-weight: normal; line-height: 17px; text-decoration: none;\" href=\"https:\/\/www.instagram.com\/p\/CO79mRbjZ6d\/?utm_source=ig_embed&amp;utm_campaign=loading\" target=\"_blank\" rel=\"noopener\">A post shared by Biotechnology (@biotechnologyguy)<\/a><\/p>\n<\/div>\n<\/blockquote>\n<p><script async src=\"\/\/www.instagram.com\/embed.js\"><\/script><\/p>\n<h2 aria-level=\"2\"><span data-contrast=\"none\">Types Of Monocytes<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Your body contains three types of monocytes:<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<ol>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"11\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Classical monocytes<\/span><\/li>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"11\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Non-classical monocytes<\/span><\/li>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"11\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><span data-contrast=\"auto\">Intermediate monocytes<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<\/ol>\n<h3><span data-contrast=\"none\">1. Classical Monocytes<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">Classical monocytes are <\/span><b><span data-contrast=\"auto\">the most common type of monocyte<\/span><\/b><span data-contrast=\"auto\"> and make up around <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC4566081\/\"><span data-contrast=\"none\">80<\/span><\/a><span data-contrast=\"auto\">% of all monocytes in your blood.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">They\u2019re important for initiating the immune response to <\/span><b><span data-contrast=\"auto\">bacterial infections<\/span><\/b><span data-contrast=\"auto\"> because they can easily bind to bacterial molecules.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Classical monocytes are also crucial for phagocytosis of foreign cells as well as the process of tissue repair and recovery after infection or injury.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<h3><span data-contrast=\"none\">2. Non-classical Monocytes<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">Non-classical monocytes make up about<\/span><a href=\"https:\/\/www.nature.com\/articles\/srep13886\" target=\"_blank\" rel=\"noopener\"> <span data-contrast=\"none\">5-10<\/span><\/a><span data-contrast=\"auto\">% of all monocytes in your blood.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Unlike classical monocytes, they <\/span><b><span data-contrast=\"auto\">don\u2019t differentiate into macrophages or dendritic cells<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Instead, non-classical monocytes <\/span><b><span data-contrast=\"auto\">patrol your blood and tissues<\/span><\/b><span data-contrast=\"auto\">; they keep an eye on the tissue health and look for the signs of infections and injury.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Non-classical monocytes <\/span><b><span data-contrast=\"auto\">clear damaged cells and debris<\/span><\/b><span data-contrast=\"auto\">, help battle inflammation and are also involved in tissue repair.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<h3><span data-contrast=\"none\">3. Intermediate Monocytes<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h3>\n<p><span data-contrast=\"auto\">Intermediate monocytes are the newly-defined subset of monocytes.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">They\u2019<\/span><span data-contrast=\"auto\">re <\/span><span data-contrast=\"auto\">included in <\/span><b><span data-contrast=\"auto\">antigen presentation<\/span><\/b><span data-contrast=\"auto\">, the stimulation of T-Cells, the body\u2019s <\/span><b><span data-contrast=\"auto\">inflammatory response<\/span><\/b><span data-contrast=\"auto\"> and tissue repair, but also in <\/span><span data-contrast=\"auto\">the development of <\/span><span data-contrast=\"auto\">some<\/span><span data-contrast=\"auto\"> diseases<\/span><span data-contrast=\"auto\">, including<\/span><span data-contrast=\"auto\"> such as atherosclerosis and rheumatoid arthritis.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p style=\"text-align: center;\"><a class=\"mceNonEditable cta-custom\" href=\"https:\/\/2023.biowars.com\/characters\" target=\"_blank\" rel=\"noopener\">Get to know the characters of the BIOWARS comic book!<\/a><\/p>\n<h2 aria-level=\"2\"><span data-contrast=\"none\">The Functions Of Monocytes<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Monocytes perform several important roles that are crucial for keeping you alive and kicking, such as:<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<ol>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"1\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Antigen presentation:<\/span><\/b><span data-contrast=\"auto\"> Antigens are molecules that are present on the surface of pathogens and other foreign substances. When monocytes differentiate into dendritic cells, they can capture and process antigens. Then, they present antigens on their surface to other immune cells, such as their fellow immune cell warriors \u2014T-cells. The reason they do this is to initiate an immune response and protect you from invaders.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<\/ol>\n<ol>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Phagocytosis:<\/span><\/b><span data-contrast=\"auto\"> Monocytes are capable of engulfing and destroying foreign particles such as bacteria, viruses and cellular debris. That way, they keep the body clear of harmful particles.<\/span><\/li>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Cytokine production:<\/span><\/b><span data-contrast=\"auto\"> Monocytes produce cytokines \u2014 signaling molecules involved in crucial processes, such as immune system cell activation, inflammation, tissue development and wound healing.<\/span><\/li>\n<li data-leveltext=\"%1.\" data-font=\"Calibri\" data-listid=\"10\" data-list-defn-props=\"{&quot;335552541&quot;:0,&quot;335559684&quot;:-1,&quot;335559685&quot;:720,&quot;335559991&quot;:360,&quot;469769242&quot;:[65533,0],&quot;469777803&quot;:&quot;left&quot;,&quot;469777804&quot;:&quot;%1.&quot;,&quot;469777815&quot;:&quot;hybridMultilevel&quot;}\" aria-setsize=\"-1\" data-aria-posinset=\"2\" data-aria-level=\"1\"><b><span data-contrast=\"auto\">Tissue repair:<\/span><\/b><span data-contrast=\"auto\"> Monocytes are like a Jack of all trades, except that they\u2019re masters of all of them. As we mentioned, monocytes can differentiate into macrophages and dendritic cells, and these cells are involved in wound healing and tissue regeneration.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/li>\n<\/ol>\n<p><span data-contrast=\"auto\">Although these functions of monocytes are beneficial for human health, at the same time, they can be harmful.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">When T-Cells become active, they will do whatever it takes to keep the host safe. Sometimes, that means mistakenly attacking the healthy tissues in the body, which can lead to <\/span><b><span data-contrast=\"auto\">tissue damage and inflammation<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">As for cytokine production, sometimes these proteins can contribute to the development of autoimmune diseases by promoting inflammation. Macrophages can do the same, too.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">When monocytes differentiate into macrophages, they can release enzymes that are harmful to healthy tissues, which can cause the development of autoimmune diseases and their progression.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<div id=\"attachment_19778\" style=\"width: 910px\" class=\"wp-caption aligncenter\"><img aria-describedby=\"caption-attachment-19778\" loading=\"lazy\" class=\"size-full wp-image-19778\" src=\"https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-patrolling-body.jpg\" alt=\"A stock image showing monocytes patrolling the body with other white blood cells.\u200b\" width=\"900\" height=\"550\" srcset=\"https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-patrolling-body.jpg 900w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-patrolling-body-300x183.jpg 300w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-patrolling-body-768x469.jpg 768w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-patrolling-body-440x269.jpg 440w, https:\/\/2023.biowars.com\/blog\/wp-content\/uploads\/2023\/05\/monocytes-patrolling-body-635x388.jpg 635w\" sizes=\"(max-width: 900px) 100vw, 900px\" \/><p id=\"caption-attachment-19778\" class=\"wp-caption-text\">Monocytes and their fellow white blood cells patrol your body, making sure everything\u2019s in perfect order. \u200b<\/p><\/div>\n<h2 aria-level=\"2\"><span data-contrast=\"none\">The Importance Of Monocytes\u00a0<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Monocytes have a big clinical significance because they can provide valuable information on a person\u2019s health.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">An increased number of monocytes in the blood is called <\/span><b><span data-contrast=\"auto\">monocytosis<\/span><\/b><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">If a person has monocytosis, that means that their body is fighting a viral, bacterial or fungal infection. Aside from indicating an <\/span><b><span data-contrast=\"auto\">infection<\/span><\/b><span data-contrast=\"auto\">, monocytosis can also be a sign of a more serious underlying condition.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">For instance, abnormal monocyte numbers can be indicative of <\/span><b><span data-contrast=\"auto\">lupus, rheumatoid arthritis<\/span><\/b><span data-contrast=\"auto\"> and <\/span><b><span data-contrast=\"auto\">bowel disease<\/span><\/b><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes can also be increased in patients with <\/span><b><span data-contrast=\"auto\">cancer<\/span><\/b><span data-contrast=\"auto\">, such as lymphoma and leukemia.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Upon seeing an increased number of monocytes, doctors are likely to request further tests and examinations to discover the cause of the problem.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes don\u2019t just indicate that a person may be sick; they can also be used to create <\/span><b><span data-contrast=\"auto\">personalized immuno therapies<\/span><\/b><span data-contrast=\"auto\">.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">For example, in <\/span><a href=\"https:\/\/www.ncbi.nlm.nih.gov\/pmc\/articles\/PMC5223236\/\" target=\"_blank\" rel=\"noopener\"><span data-contrast=\"none\">dendritic cell-based immunotherapy<\/span><\/a><span data-contrast=\"auto\">, monocytes are isolated from a patient\u2019s blood and differentiated in dendritic cells in a lab.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Then, dendritic cells are loaded with tumor antigens, and then injected back into a patient to stimulate its anti-tumor immune response.\u00a0\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Something similar is done when developing <\/span><b><span data-contrast=\"auto\">chimeric antigen receptor (CAR) T-Cell therapy<\/span><\/b><span data-contrast=\"auto\">.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">In that case, monocytes are isolated from blood and genetically engineered to express chimeric antigen receptors that target specific cancer cells.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes that express CARs are then differentiated into macrophages in a lab, then given back to the patient to kill cancer cells.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p style=\"text-align: center;\"><a class=\"mceNonEditable cta-custom\" href=\"https:\/\/2023.biowars.com\/blog\/macrophages-function\/\" target=\"_blank\" rel=\"noopener\">Discover how macrophages combat pathogens &amp; find out how they keep your organs healthy!<\/a><\/p>\n<h2 aria-level=\"2\"><span data-contrast=\"none\">A Recap On Monocytes And Their Role In The Immune System<\/span><span data-ccp-props=\"{&quot;134245418&quot;:true,&quot;134245529&quot;:true,&quot;335559738&quot;:40,&quot;335559739&quot;:0}\">\u00a0<\/span><\/h2>\n<p><span data-contrast=\"auto\">Monocytes are an essential component of the immune system and play a crucial role in defending the body against infection and disease.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Their ability to migrate to different tissues and respond to various signals makes them a vital component of both innate and adaptive immunity.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes are versatile immune cells that can differentiate into other immune cells \u2014 macrophages and dendritic cells.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The differentiation of monocytes into macrophages and dendritic cells allows for a more efficient immune response.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">When monocytes encounter a pathogen or antigen, they can differentiate into the appropriate immune cell type needed to combat the threat.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Macrophages can engulf and digest the pathogen, while dendritic cells can present antigens to T-Cells, leading to the activation of the adaptive immune response.<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">Monocytes are involved in various immune responses, including inflammation, antigen presentation, phagocytosis and cytokine production; these guys are among the most important immune cells in the human body!<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><span data-contrast=\"auto\">The study of monocytes is a fascinating area of immunology. The more scientists learn about these powerful cells, the better the chances of developing immune therapies that could cure some serious conditions and diseases, including various types of cancer.\u00a0<\/span><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n<p><b><span data-contrast=\"auto\">Do you think monocytes are cool? Are they the most powerful members of the immune system cell squad? Tell us in the comments below!<\/span><\/b><span data-ccp-props=\"{&quot;335559739&quot;:160}\">\u00a0<\/span><\/p>\n","protected":false},"excerpt":{"rendered":"<p>Discover the role of monocytes in the immune system! Did you know that your immune system can be resentful, but in a cool way?\u00a0 It remembers every single microbe it has ever fought, so if the bad guys enter your body again, your immune system recognizes them and quickly destroys them before they cause you [&hellip;]<\/p>\n","protected":false},"author":9,"featured_media":19775,"comment_status":"closed","ping_status":"closed","sticky":false,"template":"","format":"standard","meta":[],"categories":[78],"tags":[56,561,560],"yoast_head":"<!-- This site is optimized with the Yoast SEO plugin v19.10 - https:\/\/yoast.com\/wordpress\/plugins\/seo\/ -->\n<title>Monocytes 101: Types, Functions And Importance<\/title>\n<meta name=\"description\" content=\"Discover the role of monocytes in the immune system &amp; find out how these cells fight pathogens, heal wounds &amp; help tissues grow.\" \/>\n<meta name=\"robots\" content=\"index, follow, max-snippet:-1, max-image-preview:large, max-video-preview:-1\" \/>\n<link rel=\"canonical\" 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